PDE2A blocking peptide

PDE2A Blocking Peptide

Cat. Num. AAA9628391

• Gene Names: PDE2A; PDE2A1; PED2A4; cGSPDE; CGS-PDE
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: PDE2A; PDE2A Blocking Peptide; 5''-cyclic phosphodiesterase; cGMP dependent 3'5' cyclic phosphodiesterase; cGMP stimulated phosphodiesterase 1; cGMP stimulated phosphodiesterase 4; cGMP-dependent 3''; cGMP-stimulated phosphodiesterase 2; CGS PDE; CGS-PDE; cGSPDE; Cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase; PDE 2A; PDE 2A1; PDE 2A4; PDE2A_HUMAN; PDE2A1; PDE2A4; phosphodiesterase 2A; Phosphodiesterase 2A cGMP stimulated; PDE2A blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for PDE2A blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PDE2A blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 219802706
• NCBI GeneID: 5138
• NCBI Accession #: NP_001137311.1
• NCBI GenBank Nucleotide #: NM_001143839.3
• UniProt Accession #: O00408; Q5J791; Q5J792; Q5J793; Q6ZMR1; B2R646; B3KRV5; E9PGI1; F6W5Z0
• Molecular Weight: 87,235 Da
• NCBI Official Full Name: cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2
• NCBI Official Synonym Full Names: phosphodiesterase 2A, cGMP-stimulated
• NCBI Official Symbol: PDE2A
• NCBI Official Synonym Symbols: PDE2A1; PED2A4; cGSPDE; CGS-PDE
• NCBI Protein Information: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase
• UniProt Protein Name: cGMP-dependent 3',5'-cyclic phosphodiesterase
• Protein Family: cGMP-dependent 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE2A
• UniProt Synonym Gene Names: CGS-PDE; cGSPDE
• UniProt Entry Name: PDE2A_HUMAN

Uniprot Description

PDE2A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Phosphodiesterase; EC 3.1.4.17; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: presynaptic membrane; Golgi apparatus; mitochondrial matrix; axon; endoplasmic reticulum; perinuclear region of cytoplasm; dendrite; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; TPR domain binding; calcium channel activity; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cGMP binding; cyclic-nucleotide phosphodiesterase activity; drug binding; cAMP binding

Biological Process: monocyte differentiation; metabolic process; cGMP-mediated signaling; cAMP catabolic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of vascular permeability; cAMP-mediated signaling; negative regulation of cAMP biosynthetic process; negative regulation of protein import into nucleus, translocation; negative regulation of vascular permeability; regulation of cGMP metabolic process; cGMP catabolic process; blood coagulation; protein targeting to mitochondrion; positive regulation of inflammatory response