Ntrk2 blocking peptide

Mouse Ntrk2 Antibody (Center) Blocking peptide

• Gene Names: Ntrk2; Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
• Synonyms: Ntrk2; Mouse Ntrk2 Antibody (Center) Blocking peptide; BDNF/NT-3 growth factors receptor; GP145-TrkB/GP95-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Trkb; Ntrk2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of Mouse Ntrk2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 821

• Cellular Location: Cell membrane; Single-pass type I membrane protein Endosome membrane; Single-pass type I membrane protein Note: Internalized to endosomes upon ligand-binding
• Tissue Location: Widely expressed in the central and peripheral nervous system. The different forms are differentially expressed in various cell types. Isoform GP95-TRKB is specifically expressed in glial cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Ntrk2 blocking peptide

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

NCBI and Uniprot Product Information

• NCBI GI #: 136237
• NCBI GeneID: 18212
• UniProt Accession #: P15209; Q3TUF9; Q80WU0; Q91XJ9
• Molecular Weight: 83,744 Da
• NCBI Official Full Name: BDNF/NT-3 growth factors receptor
• NCBI Official Synonym Full Names: neurotrophic tyrosine kinase, receptor, type 2
• NCBI Official Symbol: Ntrk2
• NCBI Official Synonym Symbols: Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
• NCBI Protein Information: BDNF/NT-3 growth factors receptor
• UniProt Protein Name: BDNF/NT-3 growth factors receptor
• Protein Family: BDNF/NT-3 growth factors receptor
• UniProt Gene Name: Ntrk2
• UniProt Synonym Gene Names: Trkb; Trk-B
• UniProt Entry Name: NTRK2_MOUSE

Uniprot Description

TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Trk family

Cellular Component: axon; cell soma; cell surface; cytoplasm; cytosol; dendrite; dendritic spine; endosome; excitatory synapse; growth cone; integral to plasma membrane; nerve terminal; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; receptor complex; rough endoplasmic reticulum; terminal button

Molecular Function: brain-derived neurotrophic factor binding; brain-derived neurotrophic factor receptor activity; neurotrophin binding; neurotrophin receptor activity; protein binding; protein homodimerization activity; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine kinase activity

Biological Process: brain-derived neurotrophic factor receptor signaling pathway; central nervous system neuron development; cerebral cortex development; feeding behavior; glutamate secretion; learning; long-term memory; mechanoreceptor differentiation; negative regulation of neuron apoptosis; neuromuscular junction development; neuron differentiation; neuron migration; oligodendrocyte differentiation; peripheral nervous system neuron development; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of dendrite development; regulation of GTPase activity; regulation of MAPKKK cascade; regulation of metabolic process; regulation of neurotransmitter secretion; regulation of protein kinase B signaling cascade; retina development in camera-type eye; retinal rod cell development; vasculogenesis