NFKBIL1 blocking peptide

NFKBIL1 Peptide - N-terminal region

Cat. Num. AAA3229102

• Gene Names: NFKBIL1; IKBL; NFKBIL
• Applications: Western Blot
• Synonyms: NFKBIL1; NFKBIL1 Peptide - N-terminal region; NFKBIL1 blocking peptide

• Form/Format: Lyophilized powder
• Sequence Length: 381

• Applicable Applications for NFKBIL1 blocking peptide: Western Blot (WB)
• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for NFKBIL1 blocking peptide

This is a synthetic peptide designed for use in combination with anti-NFKBIL1 antibody made

Target Description: NFKBIL1 is a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isofor

Product Categories/Family for NFKBIL1 blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 222352173
• NCBI GeneID: 4795
• NCBI Accession #: NP_004998
• NCBI GenBank Nucleotide #: NM_005007
• UniProt Accession #: Q9UBC1
• Molecular Weight: 43kDa
• NCBI Official Full Name: NF-kappa-B inhibitor-like protein 1 isoform 1
• NCBI Official Synonym Full Names: NFKB inhibitor like 1
• NCBI Official Symbol: NFKBIL1
• NCBI Official Synonym Symbols: IKBL; NFKBIL
• NCBI Protein Information: NF-kappa-B inhibitor-like protein 1
• UniProt Protein Name: NF-kappa-B inhibitor-like protein 1
• Protein Family: NF-kappa-B inhibitor-like protein
• UniProt Gene Name: NFKBIL1
• UniProt Synonym Gene Names: IKBL; I-kappa-B-like protein; IkappaBL

NCBI Description

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Uniprot Description

NFKBIL1: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 6p21.33

Cellular Component: intermediate filament cytoskeleton; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production

Disease: Rheumatoid Arthritis