MYL12B blocking peptide

MYL12B Antibody(N-term) Blocking peptide

• Gene Names: MYL12A; MLCB; MRCL3; MRLC3; MYL2B; MLC-2B; HEL-S-24
• Synonyms: MYL12B; MYL12B Antibody(N-term) Blocking peptide; Myosin regulatory light chain 12B; MLC-2A; MLC-2; Myosin regulatory light chain 2-B; smooth muscle isoform; Myosin regulatory light chain 20 kDa; MLC20; Myosin regulatory light chain MRLC2; SHUJUN-1; MRLC2; MYLC2B; MYL12B blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 172

• Tissue Location: Ubiquitously expressed in various hematopoietic cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MYL12B blocking peptide

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 205829213
• NCBI GeneID: 10627
• UniProt Accession #: O14950; Q13182; Q7Z5Z4; D3DUH6; P19105
• Molecular Weight: 19,779 Da
• NCBI Official Full Name: Myosin regulatory light chain 12B
• NCBI Official Synonym Full Names: myosin light chain 12A
• NCBI Official Symbol: MYL12A
• NCBI Official Synonym Symbols: MLCB; MRCL3; MRLC3; MYL2B; MLC-2B; HEL-S-24
• NCBI Protein Information: myosin regulatory light chain 12A
• UniProt Protein Name: Myosin regulatory light chain 12B
• Protein Family: Myosin regulatory
• UniProt Gene Name: MYL12B
• UniProt Synonym Gene Names: MRLC2; MYLC2B; MLC-2; MLC20
• UniProt Entry Name: ML12B_HUMAN

NCBI Description

This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

Uniprot Description

MRLC2: non-sarcomeric myosin regulatory light chain 2. Binds calcium and plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Phosphorylation of MLC-2 in the presence of calcium and calmodulin increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. Myosin is an hexamer of 2 heavy chains and 4 light chains.

Protein type: Contractile

Chromosomal Location of Human Ortholog: 18p11.31

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: muscle contraction