MOSC2 blocking peptide

MOSC2 Antibody (C-term) Blocking Peptide

• Gene Names: MARC2; MOSC2
• Synonyms: MOSC2; MOSC2 Antibody (C-term) Blocking Peptide; Mitochondrial amidoxime reducing component 2; mARC2; 1---; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2; MOSC domain-containing protein 2; Moco sulfurase C-terminal domain-containing protein 2; MARC2; MOSC2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human MOSC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 335

• Cellular Location: Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MOSC2 blocking peptide

As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

NCBI and Uniprot Product Information

• NCBI GI #: 74760692
• NCBI GeneID: 54996
• UniProt Accession #: Q969Z3; Q0JSK7; Q5VT67; Q5VXC7; Q7L317; Q9H066; Q9NWU0; B2D0R5; D3DTB3
• Molecular Weight: 29,103 Da
• NCBI Official Full Name: Mitochondrial amidoxime reducing component 2
• NCBI Official Synonym Full Names: mitochondrial amidoxime reducing component 2
• NCBI Official Symbol: MARC2
• NCBI Official Synonym Symbols: MOSC2
• NCBI Protein Information: mitochondrial amidoxime reducing component 2
• UniProt Protein Name: Mitochondrial amidoxime reducing component 2
• UniProt Gene Name: MARC2
• UniProt Synonym Gene Names: MOSC2; mARC2; MOSC domain-containing protein 2; Moco sulfurase C-terminal domain-containing protein 2
• UniProt Entry Name: MARC2_HUMAN

NCBI Description

The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

MOSC2: As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Mitochondrial; EC 1.-.-.-

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: mitochondrion

Molecular Function: molybdenum ion binding; molybdopterin cofactor binding; nitrate reductase activity

Biological Process: nitrate metabolic process