MIB2 blocking peptide
MIB2 Blocking Peptide (N-Term)
Gene Names
MIB2; ZZZ5; ZZANK1
Synonyms
MIB2; MIB2 Blocking Peptide (N-Term); E3 ubiquitin-protein ligase MIB2; 6.3.2.-; Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1; SKD; ZZANK1; MIB2 blocking peptide
Specificity
The synthetic peptide sequence is selected from aa 236-249 of HUMAN MIB2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1013
Cellular Location
Cytoplasm. Endosome. Note: Colocalizes with endosomal compartments
Tissue Location
Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for MIB2 blocking peptide
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
115,861 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase MIB2
NCBI Official Synonym Full Names
mindbomb E3 ubiquitin protein ligase 2
NCBI Official Symbol
MIB2
NCBI Official Synonym Symbols
ZZZ5; ZZANK1
NCBI Protein Information
E3 ubiquitin-protein ligase MIB2
UniProt Protein Name
E3 ubiquitin-protein ligase MIB2
Protein Family
UniProt Gene Name
MIB2
UniProt Synonym Gene Names
SKD; ZZANK1; Novelzin
UniProt Entry Name
MIB2_HUMAN
Uniprot Description
MIB2: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; signal transducer activity; ubiquitin-protein ligase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; protein polyubiquitination
Research Articles on MIB2
Similar Products
Product Notes
The MIB2 mib2 (Catalog #AAA9230645) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MIB2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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