MGAT4B blocking peptide

MGAT4B Blocking Peptide (N-Term)

• Gene Names: MGAT4B; GNT-IV; GNT-IVB
• Synonyms: MGAT4B; MGAT4B Blocking Peptide (N-Term); Alpha-1;3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; 2.4.1.145; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; GlcNAc-T IVb; GnT-IVb; N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1;3-D-mannoside beta-1;4-N-acetylglucosaminyltransferase IVb; MGAT4B blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 32-42 of HUMAN MGAT4B
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 548

• Cellular Location: Golgi apparatus membrane; Single-pass type II membrane protein
• Tissue Location: Widely expressed. Strongly overexpressed in pancreatic cancer.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MGAT4B blocking peptide

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N- glycan biosynthesis.

NCBI and Uniprot Product Information

• NCBI GI #: 74735195
• NCBI GeneID: 11282
• UniProt Accession #: Q9UQ53; Q86TF1; Q96GH4; Q9NSK6; A8MPR0
• Molecular Weight: 64,845 Da
• NCBI Official Full Name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
• NCBI Official Synonym Full Names: mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
• NCBI Official Symbol: MGAT4B
• NCBI Official Synonym Symbols: GNT-IV; GNT-IVB
• NCBI Protein Information: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
• UniProt Protein Name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
• Protein Family: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
• UniProt Gene Name: MGAT4B
• UniProt Synonym Gene Names: GlcNAc-T IVb; GnT-IVb; N-acetylglucosaminyltransferase IVb
• UniProt Entry Name: MGT4B_HUMAN

NCBI Description

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

Uniprot Description

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.