MC5-R blocking peptide

MC5-R (E308) Peptide

Cat. Num. AAA3003070

• Gene Names: MC5R; MC2
• Applications: Blocking
• Purity: Synthetic peptide MC5-R (E308). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: MC5-R; MC5-R (E308) Peptide; Melanocortin receptor 5; MC-2; MC5R; MC5-R blocking peptide

• Specificity: This peptide can be used with studies using MBS3003069 MC5-R (E308) pAb.
• Purity/Purification: Synthetic peptide MC5-R (E308). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 325

• Applicable Applications for MC5-R blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for MC5-R blocking peptide

The melanocortin family comprises the alpha-, beta- and gamma-melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these hormones are seven-transmembrane, G protein-coupled proteins that activate adenylyl cyclase. Five melanocortin receptors have been cloned and shown to exhibit different affinities and patterns of expression. MC1-R (MSH-R) is expressed in melanocytes and corticoadrenal tissue. MC2-R is the ACTH receptor and is expressed primarily in the adrenal cortex. MC3-R has been found in specific regions of the brain and is also expressed in placenta and gut. MC4-R is expressed primarily in brain, while MC5-R is expressed at low levels in most tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 5174535
• NCBI GeneID: 4161
• NCBI Accession #: NP_005904.1
• NCBI GenBank Nucleotide #: NP_005904.1
• UniProt Accession #: P33032
• NCBI Official Full Name: melanocortin receptor 5
• NCBI Official Synonym Full Names: melanocortin 5 receptor
• NCBI Official Symbol: MC5R
• NCBI Official Synonym Symbols: MC2
• NCBI Protein Information: melanocortin receptor 5
• UniProt Protein Name: Melanocortin receptor 5
• UniProt Gene Name: MC5R
• UniProt Synonym Gene Names: MC5-R
• UniProt Entry Name: MC5R_HUMAN

NCBI Description

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

Uniprot Description

MC5R: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; melanocortin receptor activity; hormone binding

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cAMP biosynthetic process