LLGL1 blocking peptide

LLGL1 Blocking Peptide (N-term)

• Gene Names: LLGL1; DLG4; HUGL; LLGL; Lgl1; Mgl1; HUGL1; HUGL-1
• Synonyms: LLGL1; LLGL1 Blocking Peptide (N-term); Lethal (2) giant larvae protein homolog 1; LLGL; DLG4; Hugl-1; Human homolog to the D-lgl gene protein; HUGL; HUGL1; LLGL1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human LLGL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder.
• Sequence Length: 1064

• Reconstitution: Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Cellular Location: Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developping axons (By similarity).
• Peptide ID: 5021602
• Tissue Location: Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LLGL1 blocking peptide

Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.

NCBI and Uniprot Product Information

• NCBI GI #: 62912476
• NCBI GeneID: 3996
• NCBI Accession #: NP_004131.3
• NCBI GenBank Nucleotide #: NM_004140.3
• UniProt Accession #: Q15334; O00188; Q58F11; Q86UK6; A7MBM7
• Molecular Weight: 115,418 Da
• NCBI Official Full Name: lethal(2) giant larvae protein homolog 1
• NCBI Official Synonym Full Names: LLGL1, scribble cell polarity complex component
• NCBI Official Symbol: LLGL1
• NCBI Official Synonym Symbols: DLG4; HUGL; LLGL; Lgl1; Mgl1; HUGL1; HUGL-1
• NCBI Protein Information: lethal(2) giant larvae protein homolog 1
• UniProt Protein Name: Lethal(2) giant larvae protein homolog 1
• Protein Family: Lethal(2) giant larvae protein
• UniProt Gene Name: LLGL1
• UniProt Synonym Gene Names: DLG4; HUGL; HUGL1; LLGL

NCBI Description

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Uniprot Description

LLGL1: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Belongs to the WD repeat L(2)GL family.

Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: axon; cortical actin cytoskeleton; cytoplasm; cytoskeleton; early endosome membrane; Golgi cis cisterna; plasma membrane; trans-Golgi network membrane

Molecular Function: GTPase activator activity; protein binding; protein kinase binding; Rab GTPase binding; structural molecule activity; syntaxin binding

Biological Process: axonogenesis; cortical actin cytoskeleton organization and biogenesis; establishment of spindle orientation; Golgi to plasma membrane transport; neurogenesis; protein complex assembly; regulation of establishment and/or maintenance of cell polarity; regulation of exocytosis; regulation of Notch signaling pathway; regulation of protein secretion