IL1RL2 blocking peptide

IL1RL2 Antibody (Center) Blocking peptide

• Gene Names: IL1RL2; IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2
• Synonyms: IL1RL2; IL1RL2 Antibody (Center) Blocking peptide; Interleukin-1 receptor-like 2; IL-36 receptor; IL-36R; Interleukin-1 receptor-related protein 2; IL-1Rrp2; IL1R-rp2; IL1RRP2; IL1RL2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of IL1RL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 575

• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte- derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IL1RL2 blocking peptide

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 90110768
• NCBI GeneID: 8808
• UniProt Accession #: Q9HB29; Q13525; Q45H74; Q53TU8; Q587I8; A4FU63
• Molecular Weight: 51,658 Da
• NCBI Official Full Name: Interleukin-1 receptor-like 2
• NCBI Official Synonym Full Names: interleukin 1 receptor like 2
• NCBI Official Symbol: IL1RL2
• NCBI Official Synonym Symbols: IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2
• NCBI Protein Information: interleukin-1 receptor-like 2
• UniProt Protein Name: Interleukin-1 receptor-like 2
• Protein Family: Interleukin-1 receptor
• UniProt Gene Name: IL1RL2
• UniProt Synonym Gene Names: IL1RRP2; IL-36R; IL-1Rrp2; IL1R-rp2
• UniProt Entry Name: ILRL2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

Uniprot Description

IL1RL2: Receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B. Belongs to the interleukin-1 receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interleukin-1 receptor activity

Biological Process: cellular defense response; signal transduction