IL17RD blocking peptide

IL17RD Antibody (N-term) Blocking Peptide

• Gene Names: IL17RD; SEF; HH18; IL-17RD; IL17RLM
• Synonyms: IL17RD; IL17RD Antibody (N-term) Blocking Peptide; Interleukin-17 receptor D; IL-17 receptor D; IL-17RD; IL17Rhom; Interleukin-17 receptor-like protein; Sef homolog; hSef; IL17RLM; SEF; IL17RD blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 739

• Cellular Location: Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note: Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation
• Tissue Location: Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IL17RD blocking peptide

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 166063983
• NCBI GeneID: 54756
• NCBI Accession #: NP_060033
• NCBI GenBank Nucleotide #: NM_017563.4
• UniProt Accession #: Q8NFM7; Q2NKP7; Q58EZ7; Q6RVF4; Q6UWI5; Q8N113; Q8NFS0; Q9UFA0
• Molecular Weight: 79,463 Da
• NCBI Official Full Name: interleukin-17 receptor D isoform a
• NCBI Official Synonym Full Names: interleukin 17 receptor D
• NCBI Official Symbol: IL17RD
• NCBI Official Synonym Symbols: SEF; HH18; IL-17RD; IL17RLM
• NCBI Protein Information: interleukin-17 receptor D
• UniProt Protein Name: Interleukin-17 receptor D
• Protein Family: Interleukin-17 receptor
• UniProt Gene Name: IL17RD
• UniProt Synonym Gene Names: IL17RLM; SEF; IL-17 receptor D; IL-17RD; hSef
• UniProt Entry Name: I17RD_HUMAN

NCBI Description

This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

Uniprot Description

IL17RD: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; nucleoplasm

Molecular Function: interleukin-17 receptor activity

Biological Process: MAPKKK cascade

Disease: Hypogonadotropic Hypogonadism 18 With Or Without Anosmia