Rabbit anti-Human C-terminal-binding protein 1 Polyclonal Antibody | anti-CTBP1 antibody

Rabbit anti-human C-terminal-binding protein 1 polyclonal Antibody(CTBP1)

Cat. Num. AAA1494830

• Gene Names: CTBP1; BARS
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Antigen Affinity Purified
• Synonyms: C-terminal-binding protein 1; Polyclonal Antibody; Rabbit anti-human C-terminal-binding protein 1 polyclonal Antibody(CTBP1); CtBP1; CTBP1; CTBP; anti-CTBP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 429

• Applicable Applications for anti-CTBP1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Recommended dilution: WB:1:200-1000
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human C-terminal-binding protein 1 protein (20-250aa)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5961 / sc-55502 / sc-11390
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: C-terminal-binding protein 1 antibody at 6ug/mlLane 1:Hela whole cell lysateLane 2:A549 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 48,47 kDaObserved band size: 48 kDa)

Related Product Information for anti-CTBP1 antibody

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue.

NCBI and Uniprot Product Information

• NCBI GI #: 61743967
• NCBI GeneID: 1487
• NCBI Accession #: NP_001012632.1
• NCBI GenBank Nucleotide #: NM_001012614.1
• UniProt Accession #: Q13363; Q4W5N3; Q7Z2Q5
• Molecular Weight: 46,405 Da
• NCBI Official Full Name: C-terminal-binding protein 1 isoform 2
• NCBI Official Synonym Full Names: C-terminal binding protein 1
• NCBI Official Symbol: CTBP1
• NCBI Official Synonym Symbols: BARS
• NCBI Protein Information: C-terminal-binding protein 1
• UniProt Protein Name: C-terminal-binding protein 1
• Protein Family: C-terminal-binding protein
• UniProt Gene Name: CTBP1
• UniProt Synonym Gene Names: CTBP; CtBP1
• UniProt Entry Name: CTBP1_HUMAN

NCBI Description

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

CTBP1: Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)- specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: cytoplasm; nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex

Molecular Function: NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity; transcription factor activity; transcription factor binding

Biological Process: negative regulation of cell proliferation; negative regulation of histone acetylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of histone deacetylation; protein amino acid phosphorylation; regulation of cell cycle; transcription, DNA-dependent; viral genome replication; white fat cell differentiation

Disease: Wolf-hirschhorn Syndrome