Western Blot (WB)
(WB Suggested Anti-ADAM2 AntibodyTitration: 1.0 ug/mlPositive Control: Fetal Skin)
Rabbit ADAM2 Polyclonal Antibody | anti-ADAM2 antibody
ADAM2 antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-ADAM2 AntibodyTitration: 1.0 ug/mlPositive Control: Fetal Skin)
Western Blot (WB)
(WB Suggested Anti-ADAM2 AntibodyTitration: 1.0 ug/mlPositive Control: Fetal Skin)
Target Description: ADAM2 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM2 is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Uniprot Description
ADAM2: a member of the ADAM (a disintegrin and metalloprotease domain) family of Cancer-Testis Antigen (CTAs) . CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovary cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. A sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from RefSeq and UniProtKB
Protein type: Motility/polarity/chemotaxis; Cell surface; Cancer Testis Antigen (CTA); Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p11.2
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: integrin binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity
Biological Process: fusion of sperm to egg plasma membrane; binding of sperm to zona pellucida; single fertilization; adult behavior; visual learning; proteolysis; cell adhesion; multicellular organism reproduction
Research Articles on ADAM2
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Product Notes
The ADAM2 adam2 (Catalog #AAA3211389) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADAM2 antibody - N-terminal region reacts with Human, Pig, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ADAM2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ADAM2 adam2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: NFDSLPVQIT VPEKIRSIIK EGIESQASYK IVIEGKPYTV NLMQKNFLPH. It is sometimes possible for the material contained within the vial of "ADAM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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