IFITM1 blocking peptide

IFITM1 Peptide

Cat. Num. AAA153141

• Gene Names: IFITM1; 9-27; CD225; IFI17; LEU13; DSPA2a
• Applications: Blocking (BL)
• Synonyms: IFITM1; IFITM1 Peptide; 9-27; CD225; IFI17; LEU13; DSPA2a; Interferon-induced transmembrane protein 1; Dispanin subfamily A member 2a; interferon induced transmembrane protein 1 (9-27); IFITM1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 125

• Applicable Applications for IFITM1 blocking peptide: Blocking (BL)
• Application Notes: IFITM1 peptide is used for blocking the activity of IFTIM1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 14 amino acids near the carboxy terminus of human IFITM1.
• Preparation and Storage: Store IFITM1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 150010589
• NCBI GeneID: 8519
• NCBI Accession #: NP_003632
• NCBI GenBank Nucleotide #: NM_003641.3
• UniProt Accession #: P13164; Q15322; Q53XZ0; AAB25699
• Molecular Weight: 13,964 Da
• NCBI Official Full Name: interferon-induced transmembrane protein 1
• NCBI Official Synonym Full Names: interferon induced transmembrane protein 1
• NCBI Official Symbol: IFITM1
• NCBI Official Synonym Symbols: 9-27; CD225; IFI17; LEU13; DSPA2a
• NCBI Protein Information: interferon-induced transmembrane protein 1; leu-13 antigen; interferon-induced protein 17; dispanin subfamily A member 2a; interferon-inducible protein 9-27
• UniProt Protein Name: Interferon-induced transmembrane protein 1
• Protein Family: Interferon-induced transmembrane protein
• UniProt Gene Name: IFITM1
• UniProt Synonym Gene Names: CD225; IFI17; DSPA2a
• UniProt Entry Name: IFM1_HUMAN

Uniprot Description

IFITM1: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. Belongs to the CD225/Dispanin family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; receptor signaling protein activity

Biological Process: negative regulation of cell proliferation; positive regulation of osteoblast differentiation; ossification; regulation of immune response; cell surface receptor linked signal transduction; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus; cytokine and chemokine mediated signaling pathway; defense response to virus; negative regulation of cell migration