HMG14 blocking peptide

HMG14 Blocking Peptide

Gene Names

HMGN1; HMG14

Applications

Blocking/Control

Purity

The purity is >90%,tested by HPLC and MS.

Synonyms

HMG14; HMG14 Blocking Peptide; FLJ27265; FLJ31471; High mobility group (nonhistone chromosomal) protein 14; High mobility group nucleosome binding 1; High mobility group nucleosome binding domain 1; High mobility group nucleosome binding domain containing protein 1; High mobility group nucleosome-binding domain-containing protein 1; High mobility group protein 14; HMG 14; HMGN 1; HMGN1; HMGN1_HUMAN; MGC104230; MGC117425; Non-histone chromosomal protein HMG-14; Nonhistone chromosomal protein HMG 14; Nonhistone chromosomal protein HMG14; HMG14 blocking peptide

Ordering
Cat. Num. AAA9627805 For Research Use Only!

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Applicable Applications for HMG14 blocking peptide

Blocking/Control

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HMG14 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

NCBI GI #

48255933

NCBI GeneID

3150

NCBI Accession #

NP_004956.5

NCBI GenBank Nucleotide #

NM_004965.6

UniProt Accession #

P05114; Q3KQR8

Molecular Weight

10,659 Da

NCBI Official Full Name

non-histone chromosomal protein HMG-14

NCBI Official Synonym Full Names

high mobility group nucleosome binding domain 1

NCBI Official Symbol

HMGN1

NCBI Official Synonym Symbols

HMG14

NCBI Protein Information

non-histone chromosomal protein HMG-14; nonhistone chromosomal protein HMG-14; high-mobility group nucleosome binding 1; high-mobility group nucleosome binding domain 1; high-mobility group (nonhistone chromosomal) protein 14; high mobility group nucleoso

UniProt Protein Name

Non-histone chromosomal protein HMG-14

Protein Family

Non-histone chromosomal protein

UniProt Gene Name

HMGN1

UniProt Synonym Gene Names

HMG14

UniProt Entry Name

HMGN1_HUMAN

NCBI Description

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]

Uniprot Description

HMGN1: a nonhistone chromosomal protein of the HMG-14/HMG-17 protein family. Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.

Protein type: Nuclear receptor co-regulator; DNA-binding

Chromosomal Location of Human Ortholog: 21q22.2

Cellular Component: cytoplasm; nucleus; chromatin

Molecular Function: nucleosomal DNA binding; DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; transcription-coupled nucleotide-excision repair; positive regulation of RNA elongation; pyrimidine dimer repair via nucleotide-excision repair; regulation of development, heterochronic; post-embryonic camera-type eye morphogenesis; response to UV-C; regulation of epithelial cell proliferation; response to UV-B

Research Articles on HMG14

1. extracellular HMGN1 acts as a novel alarmin critical for LPS-induced development of innate and adaptive immune responses.

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Product Notes

The HMG14 hmgn1 (Catalog #AAA9627805) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's HMG14 can be used in a range of immunoassay formats including, but not limited to, Blocking/Control. Researchers should empirically determine the suitability of the HMG14 hmgn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HMG14, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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HMG14 blocking peptide