GPR124 blocking peptide

GPR124 Blocking Peptide (C-Term)

Gene Names

ADGRA2; TEM5; GPR124

Synonyms

GPR124; GPR124 Blocking Peptide (C-Term); G-protein coupled receptor 124; Tumor endothelial marker 5; KIAA1531; TEM5; GPR124 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 1279-1293 of HUMAN GPR124

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

1338

Cellular Location

Cell membrane; Multi-pass membrane protein.

Tissue Location

Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GPR124 blocking peptide

Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).

NCBI and Uniprot Product Information

NCBI GI #

221222450

NCBI GeneID

25960

UniProt Accession #

Q96PE1; Q8N3R1; Q8TEM3; Q96KB2; Q9P1Z7; Q9UFY4; A6H8W3; D3DSW4

Molecular Weight

19,530 Da

NCBI Official Full Name

Adhesion G protein-coupled receptor A2

NCBI Official Synonym Full Names

adhesion G protein-coupled receptor A2

NCBI Official Symbol

ADGRA2

NCBI Official Synonym Symbols

TEM5; GPR124

NCBI Protein Information

adhesion G protein-coupled receptor A2

UniProt Protein Name

Adhesion G protein-coupled receptor A2

UniProt Gene Name

ADGRA2

UniProt Entry Name

AGRA2_HUMAN

Uniprot Description

GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 2

Chromosomal Location of Human Ortholog: 8p11.23

Molecular Function: protein binding

Biological Process: central nervous system development; endothelial cell migration; regulation of angiogenesis; regulation of chemotaxis; sprouting angiogenesis

Research Articles on GPR124

1. Observed an inverse correlation between the expression of miR-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR-138-5p on the sensitivity to gefitinib.

Similar Products

Product Notes

The GPR124 adgra2 (Catalog #AAA9230489) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GPR124, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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GPR124 blocking peptide