Rabbit GPR124 Polyclonal Antibody | anti-GPR124 antibody

GPR124 Polyclonal Antibody

Cat. Num. AAA2529189

• Gene Names: GPR124; TEM5
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: GPR124; Polyclonal Antibody; GPR124 Polyclonal Antibody; TEM5; anti-GPR124 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.2mg/mL (varies by lot)
• Sequence Length: 1114

• Applicable Applications for anti-GPR124 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide of human GPR124
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using GPR124 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using GPR124 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-GPR124 antibody

Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis. These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.

NCBI and Uniprot Product Information

• NCBI GI #: 148922284
• NCBI GeneID: 25960
• Molecular Weight: 19,530 Da
• NCBI Official Full Name: GPR124 protein
• NCBI Official Synonym Full Names: G protein-coupled receptor 124
• NCBI Official Symbol: GPR124
• NCBI Official Synonym Symbols: TEM5
• NCBI Protein Information: G-protein coupled receptor 124; tumor endothelial marker 5
• UniProt Protein Name: G-protein coupled receptor 124
• UniProt Gene Name: GPR124
• UniProt Synonym Gene Names: KIAA1531; TEM5
• UniProt Entry Name: GP124_HUMAN

Uniprot Description

GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8p11.23

Cellular Component: cell surface; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of chemotaxis; central nervous system development; endothelial cell migration; sprouting angiogenesis; regulation of angiogenesis