GPNMB blocking peptide

GPNMB Antibody (C-term) Blocking Peptide

• Gene Names: GPNMB; NMB; HGFIN
• Synonyms: GPNMB; GPNMB Antibody (C-term) Blocking Peptide; Transmembrane glycoprotein NMB; Transmembrane glycoprotein HGFIN; HGFIN; NMB; GPNMB blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 572

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines
• Tissue Location: Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GPNMB blocking peptide

Could be a melanogenic enzyme.

NCBI and Uniprot Product Information

• NCBI GI #: 61252504
• NCBI GeneID: 10457
• UniProt Accession #: Q14956; Q6UVX1; Q8N1A1; A4D155
• Molecular Weight: 62,643 Da
• NCBI Official Full Name: Transmembrane glycoprotein NMB
• NCBI Official Synonym Full Names: glycoprotein nmb
• NCBI Official Symbol: GPNMB
• NCBI Official Synonym Symbols: NMB; HGFIN
• NCBI Protein Information: transmembrane glycoprotein NMB
• UniProt Protein Name: Transmembrane glycoprotein NMB
• Protein Family: Transmembrane glycoprotein
• UniProt Gene Name: GPNMB
• UniProt Synonym Gene Names: HGFIN; NMB
• UniProt Entry Name: GPNMB_HUMAN

NCBI Description

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GPNMB: Could be a melanogenic enzyme. Belongs to the PMEL/NMB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: integrin binding

Biological Process: cell adhesion; negative regulation of cell proliferation