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GGT2 blocking peptide

GGT2 Antibody (N-term) Blocking peptide

Gene Names
GGT2; GGT; GGT 2
Synonyms
GGT2; GGT2 Antibody (N-term) Blocking peptide; Inactive gamma-glutamyltranspeptidase 2; GGT 2; Gamma-glutamyltransferase 2; Glutathione hydrolase 2; GGT2 blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
569
Cellular Location
Cytoplasm, perinuclear region. Endoplasmic reticulum. Note: Co-localizes with calnexin in the endoplasmic reticulum
Tissue Location
Highly expressed in fetal and adult kidney and liver
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for GGT2 blocking peptide
Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
62,121 Da
NCBI Official Full Name
Inactive gamma-glutamyltranspeptidase 2
NCBI Official Synonym Full Names
gamma-glutamyltransferase 2
NCBI Official Symbol
GGT2
NCBI Official Synonym Symbols
GGT; GGT 2
NCBI Protein Information
inactive gamma-glutamyltranspeptidase 2
UniProt Protein Name
Inactive gamma-glutamyltranspeptidase 2
UniProt Gene Name
GGT2
UniProt Synonym Gene Names
GGT 2
UniProt Entry Name
GGT2_HUMAN

NCBI Description

GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

Uniprot Description

GGT2: Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Belongs to the gamma-glutamyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 3.4.19.13; EC 2.3.2.2; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: anchored to external side of plasma membrane; endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane

Molecular Function: gamma-glutamyltransferase activity

Biological Process: glutathione biosynthetic process; glutathione metabolic process; leukotriene biosynthetic process; xenobiotic metabolic process; zymogen activation

Research Articles on GGT2

Similar Products

Product Notes

The GGT2 ggt2 (Catalog #AAA9219452) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GGT2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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