GGA1 blocking peptide

GGA1 Antibody (N-term) Blocking Peptide

• Synonyms: GGA1; GGA1 Antibody (N-term) Blocking Peptide; ADP-ribosylation factor-binding protein GGA1; Gamma-adaptin-related protein 1; Golgi-localized; gamma ear-containing; ARF-binding protein 1; GGA1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human GGA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 639

• Cellular Location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein
• Tissue Location: Ubiquitously expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GGA1 blocking peptide

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

NCBI and Uniprot Product Information

• NCBI GI #: 14548066
• NCBI GeneID: 26088
• UniProt Accession #: Q9UJY5; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; A8K3D3; B0QYR7
• Molecular Weight: 72,277 Da
• NCBI Official Full Name: ADP-ribosylation factor-binding protein GGA1
• NCBI Official Synonym Full Names: golgi associated, gamma adaptin ear containing, ARF binding protein 1
• NCBI Official Symbol: GGA1
• NCBI Protein Information: ADP-ribosylation factor-binding protein GGA1
• UniProt Protein Name: ADP-ribosylation factor-binding protein GGA1
• Protein Family: ADP-ribosylation factor-binding protein
• UniProt Gene Name: GGA1
• UniProt Entry Name: GGA1_HUMAN

NCBI Description

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GGA1: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Belongs to the GGA protein family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endosome membrane; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleoplasm

Molecular Function: protein binding

Biological Process: cellular protein metabolic process; intracellular protein transport