FRK blocking peptide

FRK Antibody (N-term) Blocking Peptide

• Gene Names: FRK; GTK; RAK; PTK5
• Synonyms: FRK; FRK Antibody (N-term) Blocking Peptide; Tyrosine-protein kinase FRK; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; PTK5; RAK; FRK blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human FRK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 505

• Cellular Location: Cytoplasm. Nucleus. Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery
• Tissue Location: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FRK blocking peptide

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

NCBI and Uniprot Product Information

• NCBI GI #: 1169745
• NCBI GeneID: 2444
• UniProt Accession #: P42685; Q13128; Q9NTR5; B4DY49
• Molecular Weight: 41,980 Da
• NCBI Official Full Name: Tyrosine-protein kinase FRK
• NCBI Official Synonym Full Names: fyn related Src family tyrosine kinase
• NCBI Official Symbol: FRK
• NCBI Official Synonym Symbols: GTK; RAK; PTK5
• NCBI Protein Information: tyrosine-protein kinase FRK
• UniProt Protein Name: Tyrosine-protein kinase FRK
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: FRK
• UniProt Synonym Gene Names: PTK5; RAK
• UniProt Entry Name: FRK_HUMAN

NCBI Description

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

Uniprot Description

FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth.

Protein type: EC 2.7.10.2; Tumor suppressor; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Src family

Chromosomal Location of Human Ortholog: 6q21-q22.3

Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; intracellular; intracellular membrane-bound organelle; nucleus

Molecular Function: protein binding; receptor binding

Biological Process: cell differentiation; innate immune response; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway