FRK recombinant protein

Recombinant FRK (208-505) protein

Cat. Num. AAA389401

• Gene Names: FRK; GTK; RAK; PTK5
• Synonyms: FRK; Recombinant FRK (208-505) protein; Fyn-related kinase; Rak; FRK recombinant protein

• Host: Baculovirus
• Form/Format: Recombinant FRK (208-505) protein is supplied in 25mM HEPESNaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5mM TCEP.

• Protein Species: Human
• Tag: DYKDDDDK-Tag
• Protein Details: Recombinant FRK (208-505) protein that includes amino acids 208-505 of human FRK protein (accession number NP_002022.1) was expressed in a baculovirus expression system, and contains an N-terminal DYKDDDDK tag.
• Notes: This product was manufactured as described in Protein Details. Where possible, We has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data this product is shown.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.; Shipping Temp: Dry Ice

SDS-Page

(Recombinant FRK (208-505) protein gel 10% SDS-PAGE with Coomassie staining MW: 36.5 kDa Purity: >70%)

Related Product Information for FRK recombinant protein

Background: FRK is a non-receptor tyrosine-protein kinase that negatively regulates cell proliferation and positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth and may function as a tumor suppressor. Diseases associated with FRK include Co-Trimoxazole Allergy and Osseous Heteroplasia, Progressive.

Product Categories/Family for FRK recombinant protein

Recombinant Proteins; Kinase

NCBI and Uniprot Product Information

• NCBI GI #: 4503787
• NCBI GeneID: 2444
• NCBI Accession #: NP_002022.1
• NCBI GenBank Nucleotide #: NM_002031.2
• UniProt Accession #: P42685; Q13128; Q9NTR5
• Molecular Weight: 58,254 Da
• NCBI Official Full Name: tyrosine-protein kinase FRK
• NCBI Official Synonym Full Names: fyn-related kinase
• NCBI Official Symbol: FRK
• NCBI Official Synonym Symbols: GTK; RAK; PTK5
• NCBI Protein Information: tyrosine-protein kinase FRK; protein-tyrosine kinase 5; PTK5 protein tyrosine kinase 5; nuclear tyrosine protein kinase RAK
• UniProt Protein Name: Tyrosine-protein kinase FRK
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: FRK
• UniProt Synonym Gene Names: PTK5; RAK
• UniProt Entry Name: FRK_HUMAN

NCBI Description

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

Uniprot Description

FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth.

Protein type: Protein kinase, TK; EC 2.7.10.2; Tumor suppressor; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Src family

Chromosomal Location of Human Ortholog: 6q21-q22.3

Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; intracellular; nucleus

Molecular Function: protein binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: negative regulation of cell proliferation; cell migration; innate immune response; cell differentiation; actin cytoskeleton organization and biogenesis; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation