FMO5 blocking peptide

FMO5 Blocking Peptide (C-term)

• Synonyms: FMO5; FMO5 Blocking Peptide (C-term); Dimethylaniline monooxygenase [N-oxide-forming] 5; Dimethylaniline oxidase 5; Hepatic flavin-containing monooxygenase 5; FMO 5; FMO5 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 489-502 of HUMAN FMO5
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 533

• Cellular Location: Microsome membrane. Endoplasmic reticulum membrane
• Tissue Location: Expressed in fetal and adult liver.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FMO5 blocking peptide

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

NCBI and Uniprot Product Information

• NCBI GI #: 221316672
• NCBI GeneID: 2330
• NCBI Accession #: NP_001452.2
• NCBI GenBank Nucleotide #: NM_001461.3
• UniProt Accession #: P49326; Q8IV22; B2RBG1; C9JJD1
• Molecular Weight: 52,477 Da
• NCBI Official Full Name: dimethylaniline monooxygenase
• NCBI Official Synonym Full Names: flavin containing monooxygenase 5
• NCBI Official Symbol: FMO5
• NCBI Protein Information: dimethylaniline monooxygenase [N-oxide-forming] 5
• UniProt Protein Name: Dimethylaniline monooxygenase [N-oxide-forming] 5
• Protein Family: Dimethylaniline monooxygenase
• UniProt Gene Name: FMO5
• UniProt Synonym Gene Names: FMO 5
• UniProt Entry Name: FMO5_HUMAN

NCBI Description

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Uniprot Description

FMO5: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. Belongs to the FMO family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.13.8; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: cytoplasm; endoplasmic reticulum

Molecular Function: flavin-containing monooxygenase activity

Biological Process: drug metabolic process