Rabbit anti-Human FMO5 Polyclonal Antibody | anti-FMO5 antibody

FMO5 (Dimethylaniline Monooxygenase [N-oxide-forming] 5, Dimethylaniline Oxidase 5, Hepatic Flavin-containing Monooxygenase 5, FMO 5)

Cat. Num. AAA6009515

• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: FMO5; Polyclonal Antibody; FMO5 (Dimethylaniline Monooxygenase [N-oxide-forming] 5; Dimethylaniline Oxidase 5; Hepatic Flavin-containing Monooxygenase 5; FMO 5); Anti -FMO5 (Dimethylaniline Monooxygenase [N-oxide-forming] 5; anti-FMO5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FMO5.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MTKKRIAVIGGGVSGLSSIKCCVEEGLEPVCFERTDDIGGLWRFQENPEEGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNAQVLEYFRMYAKEFDLLKYIRFKTTVCSVKKQPDFATSGQWEVVTESEGKKEMNVFDGVMVCTGHHTNAHLPLESFPGIEKFKGQYFHSRDYKNPEGFTGKRVIIIGIGNSGGDLAVEISQTAKQVFLSTRRGAWILNRVGDYGYPADVLFSSRLTHFIWKICGQSLANKYLEKKINQRFDHEMFGLKPKHRSKDIALTE

• Applicable Applications for anti-FMO5 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human FMO5, aa1-285 (AAH35687.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of FMO5 expression in transfected 293T cell line by FMO5 polyclonal antibody. Lane 1: FMO5 transfected lysate (32.5kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-FMO5 antibody

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Product Categories/Family for anti-FMO5 antibody

Antibodies; Abs to Enzymes; Oxidase

NCBI and Uniprot Product Information

• NCBI GI #: 23274234
• NCBI GeneID: 2330
• UniProt Accession #: P49326; Q8IV22; B2RBG1; C9JJD1
• Molecular Weight: 60,221 Da
• NCBI Official Full Name: FMO5 protein
• NCBI Official Synonym Full Names: flavin containing monooxygenase 5
• NCBI Official Symbol: FMO5
• NCBI Protein Information: dimethylaniline monooxygenase [N-oxide-forming] 5; dimethylaniline monooxygenase [N-oxide-forming] 5; FMO 5; dimethylaniline oxidase 5; hepatic flavin-containing monooxygenase 5
• UniProt Protein Name: Dimethylaniline monooxygenase [N-oxide-forming] 5
• Protein Family: Dimethylaniline monooxygenase
• UniProt Gene Name: FMO5
• UniProt Synonym Gene Names: FMO 5
• UniProt Entry Name: FMO5_HUMAN

NCBI Description

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Uniprot Description

FMO5: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. Belongs to the FMO family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: FAD binding; NADP binding; flavin-containing monooxygenase activity