FHOD1 blocking peptide

FHOD1 Antibody (C-term) Blocking Peptide

• Gene Names: FHOD1; FHOS
• Synonyms: FHOD1; FHOD1 Antibody (C-term) Blocking Peptide; FH1/FH2 domain-containing protein 1; Formin homolog overexpressed in spleen 1; FHOS; Formin homology 2 domain-containing protein 1; FHOS1; FHOD1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1164

• Cellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note: Predominantly cytoplasmic
• Tissue Location: Ubiquitous. Highly expressed in spleen.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FHOD1 blocking peptide

Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.

NCBI and Uniprot Product Information

• NCBI GI #: 62512187
• NCBI GeneID: 29109
• UniProt Accession #: Q9Y613; Q59F76; Q6Y1F2; Q76MS8; Q8N521
• Molecular Weight: 126,551 Da
• NCBI Official Full Name: FH1/FH2 domain-containing protein 1
• NCBI Official Synonym Full Names: formin homology 2 domain containing 1
• NCBI Official Symbol: FHOD1
• NCBI Official Synonym Symbols: FHOS
• NCBI Protein Information: FH1/FH2 domain-containing protein 1
• UniProt Protein Name: FH1/FH2 domain-containing protein 1
• Protein Family: FH1/FH2 domain-containing protein
• UniProt Gene Name: FHOD1
• UniProt Synonym Gene Names: FHOS; FHOS1; FHOS
• UniProt Entry Name: FHOD1_HUMAN

NCBI Description

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Description

FHOD1: a cytoskeletal protein required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C- terminus.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 16q22

Cellular Component: cytoplasm; membrane; nucleus; stress fiber

Molecular Function: identical protein binding; protein binding

Biological Process: positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter