Fgfr4 blocking peptide

Mouse Fgfr4 Blocking Peptide (Center)

• Gene Names: Fgfr4; Fgfr-4
• Synonyms: Fgfr4; Mouse Fgfr4 Blocking Peptide (Center); Fibroblast growth factor receptor 4; FGFR-4; Protein-tyrosine kinase receptor MPK-11; CD334; Fgfr-4; Mpk-11; Fgfr4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 448-462 of HUMAN Fgfr4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 799

• Cellular Location: Cell membrane; Single-pass type I membrane protein Endosome. Endoplasmic reticulum Note: Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
• Tissue Location: Isoform 1 and isoform 2 are expressed in lung and proliferating myoblasts and myotubes of primary myogenic cells (at protein level). Isoform 1 and isoform 2 are expressed in liver, muscle, spleen, heart, lung, kidney and in primary myogenic cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Fgfr4 blocking peptide

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages.

NCBI and Uniprot Product Information

• NCBI GI #: 90110020
• NCBI GeneID: 14186
• UniProt Accession #: Q03142; Q27Q87; Q5J7D9; Q8C3V5; Q8CIB8
• Molecular Weight: 83,335 Da
• NCBI Official Full Name: Fibroblast growth factor receptor 4
• NCBI Official Synonym Full Names: fibroblast growth factor receptor 4
• NCBI Official Symbol: Fgfr4
• NCBI Official Synonym Symbols: Fgfr-4
• NCBI Protein Information: fibroblast growth factor receptor 4
• UniProt Protein Name: Fibroblast growth factor receptor 4
• Protein Family: Fibroblast growth factor receptor
• UniProt Gene Name: Fgfr4
• UniProt Synonym Gene Names: Fgfr-4; Mpk-11; FGFR-4
• UniProt Entry Name: FGFR4_MOUSE

Uniprot Description

FGFR4: a tyrosine-kinase receptor that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of the MAP kinase and AKT signaling pathways. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. Two isoforms of the human protein are formed by alternative splicing. This description may include information from UniProtKB

Protein type: EC 2.7.10.1; Protein kinase, TK; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; FGFR family

Cellular Component: cytoplasm; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; intercellular junction; nucleoplasm; plasma membrane; transport vesicle

Molecular Function: fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; protein binding

Biological Process: cell migration; fibroblast growth factor receptor signaling pathway; glucose homeostasis; induction of an organ; lung development; peptidyl-tyrosine phosphorylation; phosphate ion homeostasis; positive regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of proteolysis; protein amino acid autophosphorylation; regulation of lipid metabolic process; regulation of phosphorus metabolic process; vacuolar phosphate transport