FCGR3B blocking peptide

FCGR3B Blocking Peptide (N-term)

Gene Names

FCGR3B; CD16; FCG3; CD16b; FCGR3; FCR-10; FCRIII; FCRIIIb

Synonyms

FCGR3B; FCGR3B Blocking Peptide (N-term); Low affinity immunoglobulin gamma Fc region receptor III-B; Fc-gamma RIII-beta; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb; FcR-10; IgG Fc receptor III-1; CD16b; CD16B; FCG3; FCGR3; IGFR3; FCGR3B blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 32-47 of HUMAN FCGR3B

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

233

Cellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note: Secreted after cleavage

Tissue Location

Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FCGR3B blocking peptide

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

NCBI and Uniprot Product Information

NCBI GI #

7994572

NCBI GeneID

2215

UniProt Accession #

O75015

Molecular Weight

26,216 Da

NCBI Official Full Name

Low affinity immunoglobulin gamma Fc region receptor III-B

NCBI Official Synonym Full Names

Fc fragment of IgG receptor IIIb

NCBI Official Symbol

FCGR3B

NCBI Official Synonym Symbols

CD16; FCG3; CD16b; FCGR3; FCR-10; FCRIII; FCRIIIb

NCBI Protein Information

low affinity immunoglobulin gamma Fc region receptor III-B

UniProt Protein Name

Low affinity immunoglobulin gamma Fc region receptor III-B

Protein Family

Low affinity immunoglobulin gamma Fc region receptor

UniProt Gene Name

FCGR3B

UniProt Synonym Gene Names

CD16B; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb

UniProt Entry Name

FCG3B_HUMAN

NCBI Description

The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]

Uniprot Description

Research Articles on FCGR3B

1. Data show that gains or losses in copy numbers of Fc gamma receptors FCGR3A were less frequent than for FCGR3B and FCGR2C.

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Product Notes

The FCGR3B fcgr3b (Catalog #AAA9229233) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FCGR3B, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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FCGR3B blocking peptide