ESRP1 blocking peptide

ESRP1 Antibody (N-term) Blocking peptide

• Gene Names: ESRP1; RBM35A; RMB35A
• Synonyms: ESRP1; ESRP1 Antibody (N-term) Blocking peptide; Epithelial splicing regulatory protein 1; RNA-binding motif protein 35A; RNA-binding protein 35A; RBM35A; ESRP1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 659

• Cellular Location: Nucleus.
• Tissue Location: Epithelial cell-specific.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ESRP1 blocking peptide

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

NCBI and Uniprot Product Information

• NCBI GI #: 170763529
• NCBI GeneID: 54845
• NCBI Accession #: NP_001116298.1
• NCBI GenBank Nucleotide #: NM_001122826.1
• UniProt Accession #: Q6NXG1; Q2M2B0; Q499G3; Q6PJ86; Q9NXL8; A6NHA8; A8MPX1; E9PB47
• Molecular Weight: 73,133 Da
• NCBI Official Full Name: epithelial splicing regulatory protein 1 isoform 3
• NCBI Official Synonym Full Names: epithelial splicing regulatory protein 1
• NCBI Official Symbol: ESRP1
• NCBI Official Synonym Symbols: RBM35A; RMB35A
• NCBI Protein Information: epithelial splicing regulatory protein 1
• UniProt Protein Name: Epithelial splicing regulatory protein 1
• Protein Family: Epithelial splicing regulatory protein
• UniProt Gene Name: ESRP1
• UniProt Synonym Gene Names: RBM35A
• UniProt Entry Name: ESRP1_HUMAN

NCBI Description

ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

Uniprot Description

RBM35A: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Belongs to the ESRP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: mRNA binding; protein binding

Biological Process: fibroblast growth factor receptor signaling pathway; regulation of RNA splicing