ERAL1 blocking peptide

ERAL1 Antibody (Center) Blocking Peptide

• Gene Names: ERAL1; ERA; CEGA; ERA-W; H-ERA; ERAL1A; HERA-A; HERA-B
• Synonyms: ERAL1; ERAL1 Antibody (Center) Blocking Peptide; GTPase Era; mitochondrial; H-ERA; hERA; Conserved ERA-like GTPase; CEGA; ERA-W; ERA-like protein 1; HERA; ERAL1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 437

• Cellular Location: Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note: Localizes on the matrix side on the mitochondrial inner membrane
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ERAL1 blocking peptide

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

NCBI and Uniprot Product Information

• NCBI GI #: 57015286
• NCBI GeneID: 26284
• UniProt Accession #: O75616; O75617; Q8WUY4; Q96LE2; Q96TC0; B3KN21; C9JEC6
• Molecular Weight: 30,040 Da
• NCBI Official Full Name: GTPase Era, mitochondrial
• NCBI Official Synonym Full Names: Era like 12S mitochondrial rRNA chaperone 1
• NCBI Official Symbol: ERAL1
• NCBI Official Synonym Symbols: ERA; CEGA; ERA-W; H-ERA; ERAL1A; HERA-A; HERA-B
• NCBI Protein Information: GTPase Era, mitochondrial
• UniProt Protein Name: GTPase Era, mitochondrial
• UniProt Gene Name: ERAL1
• UniProt Synonym Gene Names: HERA; H-ERA; hERA; CEGA
• UniProt Entry Name: ERAL1_HUMAN

NCBI Description

The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Description

ERAL1: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. Belongs to the Era/MnmE GTP-binding protein family. Era subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: actin cytoskeleton; cytoplasm; intermediate filament cytoskeleton; mitochondrial matrix; mitochondrion

Molecular Function: protein binding; ribosomal small subunit binding; rRNA binding

Biological Process: ribosomal small subunit assembly and maintenance