Rabbit anti-Human ERAL1 Polyclonal Antibody | anti-ERAL1 antibody

ERAL1 Antibody (Center)

Cat. Num. AAA9207181

• Gene Names: ERAL1; ERA; H-ERA; ERAL1A; HERA-A; HERA-B
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: ERAL1; Polyclonal Antibody; ERAL1 Antibody (Center); GTPase Era; mitochondrial; H-ERA; hERA; Conserved ERA-like GTPase; CEGA; ERA-W; ERA-like protein 1; HERA; anti-ERAL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This ERAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human ERAL1.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 152-180
• Sequence Length: 276

• Applicable Applications for anti-ERAL1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(ERAL1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ERAL1 antibody detected the ERAL1 protein (arrow).)

Related Product Information for anti-ERAL1 antibody

Era is an essential GTPase that is required for proper cell cycle progression and cell division in E. coli. Human homologues have been isolated which have been designated ERAL1A and ERAL1B.

Product Categories/Family for anti-ERAL1 antibody

Signal Transduction

References

Dennerlein, S., et al. Biochem. J. 430(3):551-558(2010)
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Akiyama, T., et al. Genes Cells 6(11):987-1001(2001)
Britton, R.A., et al. Genomics 67(1):78-82(2000)

NCBI and Uniprot Product Information

• NCBI GI #: 24307899
• NCBI GeneID: 26284
• NCBI Accession #: NP_005693.1
• NCBI GenBank Nucleotide #: NM_005702.2
• UniProt Accession #: O75616; O75617; Q8WUY4; Q96LE2; Q96TC0; B3KN21; C9JEC6
• Molecular Weight: 48350
• NCBI Official Full Name: GTPase Era, mitochondrial
• NCBI Official Synonym Full Names: Era-like 12S mitochondrial rRNA chaperone 1
• NCBI Official Symbol: ERAL1
• NCBI Official Synonym Symbols: ERA; H-ERA; ERAL1A; HERA-A; HERA-B
• NCBI Protein Information: GTPase Era, mitochondrial
• UniProt Protein Name: GTPase Era, mitochondrial
• UniProt Gene Name: ERAL1
• UniProt Synonym Gene Names: HERA; H-ERA; hERA; CEGA
• UniProt Entry Name: ERAL1_HUMAN

Uniprot Description

ERAL1: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. Belongs to the Era/MnmE GTP-binding protein family. Era subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: intermediate filament cytoskeleton; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; actin cytoskeleton

Molecular Function: rRNA binding; GTP binding; ribosomal small subunit binding

Biological Process: ribosomal small subunit assembly and maintenance