ELL blocking peptide

ELL Antibody (C-term) Blocking Peptide

• Gene Names: ELL; MEN; ELL1; PPP1R68; C19orf17
• Synonyms: ELL; ELL Antibody (C-term) Blocking Peptide; RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein; C19orf17; ELL blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 621

• Cellular Location: Nucleus. Nucleus speckle. Nucleus, Cajal body. Note: Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes
• Tissue Location: Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ELL blocking peptide

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.

NCBI and Uniprot Product Information

• NCBI GI #: 1706635
• NCBI GeneID: 8178
• UniProt Accession #: P55199
• Molecular Weight: 68,265 Da
• NCBI Official Full Name: RNA polymerase II elongation factor ELL
• NCBI Official Synonym Full Names: elongation factor for RNA polymerase II
• NCBI Official Symbol: ELL
• NCBI Official Synonym Symbols: MEN; ELL1; PPP1R68; C19orf17
• NCBI Protein Information: RNA polymerase II elongation factor ELL
• UniProt Protein Name: RNA polymerase II elongation factor ELL
• Protein Family: ELL-associated factor
• UniProt Gene Name: ELL
• UniProt Synonym Gene Names: C19orf17
• UniProt Entry Name: ELL_HUMAN

Uniprot Description

ELL: Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein. Belongs to the ELL/occludin family.

Protein type: Nuclear receptor co-regulator; Transcription initiation complex; Oncoprotein

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: actin cytoskeleton; Cajal body; cytoplasm; nuclear speck; nucleoplasm; nucleus; plasma membrane; transcription elongation factor complex

Molecular Function: phosphatase binding; protein binding

Biological Process: positive regulation of RNA elongation; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter