DOR-1 blocking peptide

DOR-1 (F345) Peptide

Cat. Num. AAA3003503

• Gene Names: OPRD1; DOP; DOR; DOR1; OPRD
• Applications: Blocking
• Purity: Synthetic peptide DOR-1 (F345). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: DOR-1; DOR-1 (F345) Peptide; OPRD1; OPRD; DOR-1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3003502 DOR-1 (F345) pAb.
• Purity/Purification: Synthetic peptide DOR-1 (F345). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 372

• Applicable Applications for DOR-1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for DOR-1 blocking peptide

The opioid receptors are G-protein coupled, seven-transmembrane domain receptors for enkephalins, endorphins, and dynorphins. Three different opioid receptor subtypes (kappa, delta, and mu) were first identified by their different selectivities for various naturally occurring alkaloid opioid ligands, and subsequently confirmed by molecular cloning. The amino acid sequences of the opioid receptor subtypes are ~70% homologous, and are similar to somatostatin receptors (SSTRs) showing ~40 % homology with SSTR1. G-protein binding is thought to occur at the third intracellular loop of the opioid receptors, which is also the location of consensus sequences for phosphorylation of the receptor. Interestingly, the genes encoding the specific receptor subtypes are found on different chromosomes in both the human and mouse genomes.

NCBI and Uniprot Product Information

• NCBI GI #: 63477962
• NCBI GeneID: 4985
• NCBI Accession #: NP_000902.3
• NCBI GenBank Nucleotide #: NP_000902.3
• UniProt Accession #: P41143
• NCBI Official Full Name: delta-type opioid receptor
• NCBI Official Synonym Full Names: opioid receptor delta 1
• NCBI Official Symbol: OPRD1
• NCBI Official Synonym Symbols: DOP; DOR; DOR1; OPRD
• NCBI Protein Information: delta-type opioid receptor
• UniProt Protein Name: Delta-type opioid receptor
• UniProt Gene Name: OPRD1
• UniProt Synonym Gene Names: OPRD; D-OR-1; DOR-1
• UniProt Entry Name: OPRD_HUMAN

Uniprot Description

DOR-1: delta opioid receptor, a G-protein coupled receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. Receptor for enkephalins.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.1-p34.3

Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; nerve terminal; intrinsic to plasma membrane; vesicle; lipid raft

Molecular Function: neuropeptide binding; protein binding; opioid receptor activity

Biological Process: adult locomotory behavior; activation of CREB transcription factor; regulation of calcium ion transport; sensory perception of pain; positive regulation of peptidyl-serine phosphorylation; G-protein coupled receptor protein signaling pathway; negative regulation of protein oligomerization; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; regulation of mitochondrial membrane potential; neuropeptide signaling pathway; protein import into nucleus, translocation; immune response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway