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Western Blot (WB) (Western Blot analysis of OPRD1 on different lysates using anti-OPRD1 antibody at 1/1,000 dilution. Positive control: Lane 1: HUVEC Lane 2: Rat brain)

Rabbit OPRD1 Polyclonal Antibody | anti-OPRD1 antibody

OPRD1 Polyclonal Antibody

Gene Names
OPRD1; DOP; DOR; DOR1; OPRD
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Flow Cytometry, Functional Assay
Purity
ProA affinity purified
Synonyms
OPRD1; Polyclonal Antibody; OPRD1 Polyclonal Antibody; D-OR-1; DOR-1; Delta type opioid receptor; Delta type opioid receptor DOR 1; Delta type opioid receptor DOR1; Delta-type opioid receptor; DOR 1; DOR1; mDOR; Nbor; Opioid receptor delta 1; OPRD 1; OPRD; Oprd1; anti-OPRD1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
OPRD1 polyclonal antibody detects endogenous levels of OPRD1 protein.
Purity/Purification
ProA affinity purified
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
372
Applicable Applications for anti-OPRD1 antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes
WB: 1:1,000
FC/FACS: 1:50-1:100
Immunogen
recombinant protein
Preparation and Storage
Store at 4 degree C after thawing.
Aliquot store at -20 degree C or -80 degree C.
Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of OPRD1 on different lysates using anti-OPRD1 antibody at 1/1,000 dilution. Positive control: Lane 1: HUVEC Lane 2: Rat brain)

Western Blot (WB) (Western Blot analysis of OPRD1 on different lysates using anti-OPRD1 antibody at 1/1,000 dilution. Positive control: Lane 1: HUVEC Lane 2: Rat brain)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of SH-SY-5Y cells with OPRD1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody)

Flow Cytometry (FC/FACS) (Flow cytometric analysis of SH-SY-5Y cells with OPRD1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody)
Related Product Information for anti-OPRD1 antibody
Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins. The three opioid receptor types are highly homologous and belong to the superfamily of G protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
40kDa
NCBI Official Full Name
delta-type opioid receptor
NCBI Official Synonym Full Names
opioid receptor delta 1
NCBI Official Symbol
OPRD1
NCBI Official Synonym Symbols
DOP; DOR; DOR1; OPRD
NCBI Protein Information
delta-type opioid receptor
UniProt Protein Name
Delta-type opioid receptor
UniProt Gene Name
OPRD1
UniProt Synonym Gene Names
OPRD; D-OR-1; DOR-1
UniProt Entry Name
OPRD_HUMAN

Uniprot Description

DOR-1: delta opioid receptor, a G-protein coupled receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. Receptor for enkephalins.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.1-p34.3

Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; nerve terminal; intrinsic to plasma membrane; vesicle; lipid raft

Molecular Function: neuropeptide binding; protein binding; opioid receptor activity

Biological Process: adult locomotory behavior; activation of CREB transcription factor; regulation of calcium ion transport; sensory perception of pain; positive regulation of peptidyl-serine phosphorylation; G-protein coupled receptor protein signaling pathway; negative regulation of protein oligomerization; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; regulation of mitochondrial membrane potential; neuropeptide signaling pathway; protein import into nucleus, translocation; immune response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway

Research Articles on OPRD1

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Product Notes

The OPRD1 oprd1 (Catalog #AAA3013171) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OPRD1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's OPRD1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Flow Cytometry (FC/FACS). WB: 1:1,000 FC/FACS: 1:50-1:100. Researchers should empirically determine the suitability of the OPRD1 oprd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OPRD1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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