CHST8 blocking peptide

CHST8 Antibody (Center) Blocking peptide

• Gene Names: CHST8; PSS3; GalNAc4ST; GALNAC4ST1
• Synonyms: CHST8; CHST8 Antibody (Center) Blocking peptide; Carbohydrate sulfotransferase 8; 282-; GalNAc-4-O-sulfotransferase 1; GalNAc-4-ST1; GalNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1; CHST8 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 424

• Cellular Location: Golgi apparatus membrane; Single-pass type II membrane protein
• Tissue Location: Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed in the epidermis. Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary gland and trachea
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CHST8 blocking peptide

Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.

NCBI and Uniprot Product Information

• NCBI GI #: 61212124
• NCBI GeneID: 64377
• UniProt Accession #: Q9H2A9; Q9H3N2
• Molecular Weight: 48,834 Da
• NCBI Official Full Name: Carbohydrate sulfotransferase 8
• NCBI Official Synonym Full Names: carbohydrate sulfotransferase 8
• NCBI Official Symbol: CHST8
• NCBI Official Synonym Symbols: PSS3; GalNAc4ST; GALNAC4ST1
• NCBI Protein Information: carbohydrate sulfotransferase 8
• UniProt Protein Name: Carbohydrate sulfotransferase 8
• Protein Family: Carbohydrate sulfotransferase
• UniProt Gene Name: CHST8
• UniProt Synonym Gene Names: GalNAc-4-ST1; GalNAc4ST-1
• UniProt Entry Name: CHST8_HUMAN

NCBI Description

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

CHST8: Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. CHST8 mutations may be a cause of generalized non- inflammatory peeling skin syndrome type A (PubMed:22289416). Peeling skin syndrome (PSS) is a genodermatosis characterized by continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels. Belongs to the sulfotransferase 2 family.

Protein type: Transferase; EC 2.8.2.-; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: Golgi membrane

Molecular Function: N-acetylgalactosamine 4-O-sulfotransferase activity

Biological Process: hormone biosynthetic process; proteoglycan biosynthetic process; sulfur metabolic process

Disease: Peeling Skin Syndrome 3