Cdkn1b blocking peptide

Mouse Cdkn1b Antibody (N-term) Blocking Peptide

• Gene Names: Cdkn1b; p27; Kip1; p27Kip1; AA408329; AI843786
• Synonyms: Cdkn1b; Mouse Cdkn1b Antibody (N-term) Blocking Peptide; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1; Cdkn1b blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 197

• Cellular Location: Nucleus. Cytoplasm. Endosome. Note: Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-197, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser- 10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 (By similarity). Colocalizes at the endosome with SNX6; this leads to lysosomal degradation
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Cdkn1b blocking peptide

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of cyclin D-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

NCBI and Uniprot Product Information

• NCBI GI #: 408360008
• NCBI GeneID: 12576
• UniProt Accession #: P46414; Q8BG74
• Molecular Weight: 22,193 Da
• NCBI Official Full Name: Cyclin-dependent kinase inhibitor 1B
• NCBI Official Synonym Full Names: cyclin-dependent kinase inhibitor 1B
• NCBI Official Symbol: Cdkn1b
• NCBI Official Synonym Symbols: p27; Kip1; p27Kip1; AA408329; AI843786
• NCBI Protein Information: cyclin-dependent kinase inhibitor 1B
• UniProt Protein Name: Cyclin-dependent kinase inhibitor 1B
• Protein Family: Cyclin-dependent kinase inhibitor
• UniProt Gene Name: Cdkn1b
• UniProt Entry Name: CDN1B_MOUSE

Uniprot Description

p27Kip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Protein type: Inhibitor; Oncoprotein; Cell cycle regulation; Protein kinase, regulatory subunit

Cellular Component: cytoplasm; cytosol; nucleus; protein complex

Molecular Function: caspase activator activity; chaperone binding; cyclin-dependent protein kinase inhibitor activity; Hsp70 protein binding; protein binding; protein complex binding; protein phosphatase binding

Biological Process: autophagic cell death; caspase activation; cell cycle arrest; cell death; G1/S transition of mitotic cell cycle; inner ear development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell motility; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of epithelial cell proliferation; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of microtubule polymerization; potassium ion transport; sensory perception of sound