CDK5R1 blocking peptide

CDK5R1 Blocking Peptide (N-term)

• Gene Names: CDK5R1; p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a
• Synonyms: CDK5R1; CDK5R1 Blocking Peptide (N-term); Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; p35; p25; Tau protein kinase II 23 kDa subunit; p23; CDK5R; NCK5A; CDK5R1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 30-44 of HUMAN CDK5R1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 307

• Cellular Location: Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side. Note: In the primary cortical neurons, p35 is present in the peripheries and nerve terminals
• Tissue Location: Brain and neuron specific.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CDK5R1 blocking peptide

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

NCBI and Uniprot Product Information

• NCBI GI #: 2498217
• NCBI GeneID: 8851
• UniProt Accession #: Q15078; Q5U0G3; E1P664
• Molecular Weight: 34,060 Da
• NCBI Official Full Name: Cyclin-dependent kinase 5 activator 1
• NCBI Official Synonym Full Names: cyclin dependent kinase 5 regulatory subunit 1
• NCBI Official Symbol: CDK5R1
• NCBI Official Synonym Symbols: p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a
• NCBI Protein Information: cyclin-dependent kinase 5 activator 1
• UniProt Protein Name: Cyclin-dependent kinase 5 activator 1
• Protein Family: Cyclin-dependent kinase 5 activator
• UniProt Gene Name: CDK5R1
• UniProt Synonym Gene Names: CDK5R; NCK5A; CDK5 activator 1; p35; p25; p23
• UniProt Entry Name: CD5R1_HUMAN

NCBI Description

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

Uniprot Description

CDK5R1: activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: axon; cell soma; contractile fiber; cytoplasm; cytosol; dendrite; dendritic spine; growth cone; intracellular membrane-bound organelle; membrane; neuromuscular junction; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic density

Molecular Function: cadherin binding; calcium ion binding; kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activator activity

Biological Process: acetylcholine receptor signaling, muscarinic pathway; axon guidance; axonal fasciculation; brain development; cell proliferation; ephrin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; negative regulation of transcription, DNA-dependent; neurite development; neuron adhesion; neuron differentiation; neuron migration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of neuron apoptosis; regulation of cyclin-dependent protein kinase activity