CCR3 blocking peptide

CCR3 Peptide

Cat. Num. AAA152675

• Gene Names: CCR3; CKR3; CD193; CMKBR3; CC-CKR-3
• Applications: Blocking (BL)
• Synonyms: CCR3; CCR3 Peptide; CKR3; CD193; CMKBR3; CC-CKR-3; C-C chemokine receptor type 3; Eosinophil eotaxin receptor; C-C CKR-3; chemokine (C-C motif) receptor 3; CCR3 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 355

• Applicable Applications for CCR3 blocking peptide: Blocking (BL)
• Application Notes: CCR3 peptide is used for blocking the activity of CCR3 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 14 amino acids near the carboxy terminus of human CCR3.
• Preparation and Storage: Store CCR3 peptide at -20 degree C, stable for one year.

Western Blot (WB)

(Western blot analysis of CCR3 in human spleen tissue lysates with CCR3 antibody at 1 (lane 1) and 2 μg/mL (lane 2), and 2 μg/mL in the presence of blocking peptide. (1105P) (lane 3). Below: Immunohistochemistry of CCR3 in human spleen tissue with CCR3 antibody at 10 μg/mL.)

NCBI and Uniprot Product Information

• NCBI GI #: 30581170
• NCBI GeneID: 1232
• NCBI Accession #: NP_847899
• NCBI GenBank Nucleotide #: NM_178329.2
• UniProt Accession #: P51677; Q15748; Q2YDB9; Q86WD2; Q8TDP6; Q9ULY8; B3KVQ1; F5GWL6
• Molecular Weight: 43,453 Da
• NCBI Official Full Name: C-C chemokine receptor type 3 isoform 1
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 3
• NCBI Official Symbol: CCR3
• NCBI Official Synonym Symbols: CKR3; CD193; CMKBR3; CC-CKR-3
• NCBI Protein Information: C-C chemokine receptor type 3; CCR-3; C-C CKR-3; b-chemokine receptor; CC chemokine receptor 3; eosinophil eotaxin receptor; eosinophil CC chemokine receptor 3
• UniProt Protein Name: C-C chemokine receptor type 3
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR3
• UniProt Synonym Gene Names: CMKBR3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3
• UniProt Entry Name: CCR3_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Uniprot Description

CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, cytokine; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; viral reproduction; cellular defense response; positive regulation of endothelial cell proliferation; chemotaxis; inflammatory response; cell adhesion