B4GALNT3 blocking peptide

B4GALNT3 Antibody (Center) Blocking peptide

• Synonyms: B4GALNT3; B4GALNT3 Antibody (Center) Blocking peptide; Beta-1;4-N-acetylgalactosaminyltransferase 3; B4GalNAcT3; Beta4GalNAc-T3; Beta4GalNAcT3; Beta-1;4-N-acetylgalactosaminyltransferase III; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2; NGalNAc-T2; B4GALNT3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of B4GALNT3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 998

• Cellular Location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note: Localizes to apical Golgi
• Tissue Location: Highly expressed in testis, colon and stomach. Weakly expressed in other tissues.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for B4GALNT3 blocking peptide

Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'- diacetyllactosediamine formation on gastric mucosa.

NCBI and Uniprot Product Information

• NCBI GI #: 161789024
• NCBI GeneID: 283358
• UniProt Accession #: Q6L9W6; Q6ZNC1; Q8N7T6
• Molecular Weight: 114,975 Da
• NCBI Official Full Name: Beta-1,4-N-acetylgalactosaminyltransferase 3
• NCBI Official Synonym Full Names: beta-1,4-N-acetyl-galactosaminyltransferase 3
• NCBI Official Symbol: B4GALNT3
• NCBI Protein Information: beta-1,4-N-acetylgalactosaminyltransferase 3
• UniProt Protein Name: Beta-1,4-N-acetylgalactosaminyltransferase 3
• Protein Family: Beta-1,4-N-acetylgalactosaminyltransferase
• UniProt Gene Name: B4GALNT3
• UniProt Synonym Gene Names: B4GalNAcT3; Beta4GalNAc-T3; Beta4GalNAcT3; NGalNAc-T2
• UniProt Entry Name: B4GN3_HUMAN

NCBI Description

B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]

Uniprot Description

B4GALNT3: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'- diacetyllactosediamine formation on gastric mucosa. Belongs to the chondroitin N- acetylgalactosaminyltransferase family.

Protein type: Membrane protein, integral; Transferase; EC 2.4.1.244

Chromosomal Location of Human Ortholog: 12p13.33

Molecular Function: acetylgalactosaminyltransferase activity