ATG5 blocking peptide

ATG5 Peptide

Cat. Num. AAA153237

• Gene Names: ATG5; ASP; APG5; APG5L; hAPG5; APG5-LIKE
• Applications: Blocking (BL)
• Synonyms: ATG5; ATG5 Peptide; ASP; APG5; APG5L; hAPG5; APG5-LIKE; ATG5 autophagy related 5 homolog (S. cerevisiae); ATG5 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 275

• Applicable Applications for ATG5 blocking peptide: Blocking (BL)
• Application Notes: ATG5 peptide is used for blocking the activity of ATG5 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acids near the amino terminus of human ATG5.
• Preparation and Storage: Store ATG5 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 119568800
• NCBI GeneID: 9474
• UniProt Accession #: A9UGY9; Q9H1Y0
• Molecular Weight: 32,447 Da
• NCBI Official Full Name: ATG5 autophagy related 5 homolog (S. cerevisiae), isoform CRA_b
• NCBI Official Synonym Full Names: autophagy related 5
• NCBI Official Symbol: ATG5
• NCBI Official Synonym Symbols: ASP; APG5; APG5L; hAPG5; APG5-LIKE
• NCBI Protein Information: autophagy protein 5; apoptosis-specific protein; ATG5 autophagy related 5 homolog
• UniProt Protein Name: Autophagy protein 5
• Protein Family: Autophagy protein
• UniProt Gene Name: ATG5
• UniProt Entry Name: A9UGY9_HUMAN

Uniprot Description

ATG5: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Autophagy; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: membrane; cytoplasm; pre-autophagosomal structure membrane; autophagic vacuole; axoneme

Molecular Function: protein binding; APG8 conjugating enzyme activity

Biological Process: response to drug; response to fungus; apoptosis; ventricular cardiac muscle cell development; C-terminal protein lipidation; post-translational protein modification; vasodilation; regulation of release of sequestered calcium ion into cytosol; cellular response to nitrogen starvation; heart contraction; regulation of cytokine secretion during immune response; mitochondrion degradation; autophagy; innate immune response; negative regulation of protein ubiquitination; blood vessel remodeling; negative regulation of interferon type I production; otolith development; autophagic vacuole formation; negative regulation of apoptosis