AOC3 blocking peptide

AOC3 Antibody (Center) Blocking Peptide

• Gene Names: AOC3; HPAO; SSAO; VAP1; VAP-1
• Synonyms: AOC3; AOC3 Antibody (Center) Blocking Peptide; Membrane primary amine oxidase; Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; VAP1; AOC3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human AOC3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 763

• Cellular Location: Cell membrane; Single-pass type II membrane protein
• Tissue Location: Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AOC3 blocking peptide

Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 2501336
• NCBI GeneID: 8639
• UniProt Accession #: Q16853; Q45F94; B2RCI5; K7ESB3; L0L8N9
• Molecular Weight: 24,533 Da
• NCBI Official Full Name: Membrane primary amine oxidase
• NCBI Official Synonym Full Names: amine oxidase, copper containing 3
• NCBI Official Symbol: AOC3
• NCBI Official Synonym Symbols: HPAO; SSAO; VAP1; VAP-1
• NCBI Protein Information: membrane primary amine oxidase
• UniProt Protein Name: Membrane primary amine oxidase
• Protein Family: Allene oxide cyclase
• UniProt Gene Name: AOC3
• UniProt Synonym Gene Names: VAP1; SSAO; VAP-1
• UniProt Entry Name: AOC3_HUMAN

NCBI Description

This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Uniprot Description

AOC3: Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis. Belongs to the copper/topaquinone oxidase family.

Protein type: Amino Acid Metabolism - phenylalanine; Membrane protein, integral; Cell adhesion; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - glycine, serine and threonine; EC 1.4.3.21; Oxidoreductase; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cell surface; cytoplasm; early endosome; endoplasmic reticulum; Golgi apparatus; integral to membrane; microvillus; plasma membrane

Molecular Function: amine oxidase activity; calcium ion binding; copper ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; quinone binding

Biological Process: amine metabolic process; cell adhesion; inflammatory response; response to antibiotic; xenobiotic metabolic process