Human Paired immunoglobulin-like type 2 receptor beta ELISA Kit | PILRB elisa kit
Human Paired immunoglobulin-like type 2 receptor beta ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
Uniprot Description
PILRB: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: integral to plasma membrane
Molecular Function: MHC class I protein binding; protein binding
Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on PILRB
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Product Notes
The Human PILRB pilrb (Catalog #AAA2881696) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2881696 ELISA Kit recognizes Human PILRB. It is sometimes possible for the material contained within the vial of "Paired immunoglobulin-like type 2 receptor beta, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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