ADRA1B blocking peptide

ADRA1B Blocking Peptide (C-term)

• Gene Names: ADRA1B; ADRA1; ALPHA1BAR
• Synonyms: ADRA1B; ADRA1B Blocking Peptide (C-term); Alpha-1B adrenergic receptor; Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor; ADRA1B blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 395-409 of HUMAN ADRA1B
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 520

• Cellular Location: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ADRA1B blocking peptide

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 4501959
• NCBI GeneID: 147
• NCBI Accession #: NP_000670.1
• NCBI GenBank Nucleotide #: NM_000679.3
• UniProt Accession #: P35368; B0LPE1
• Molecular Weight: 56,836 Da
• NCBI Official Full Name: alpha-1B adrenergic receptor
• NCBI Official Synonym Full Names: adrenoceptor alpha 1B
• NCBI Official Symbol: ADRA1B
• NCBI Official Synonym Symbols: ADRA1; ALPHA1BAR
• NCBI Protein Information: alpha-1B adrenergic receptor
• UniProt Protein Name: Alpha-1B adrenergic receptor
• Protein Family: Alpha-1B adrenergic receptor
• UniProt Gene Name: ADRA1B
• UniProt Synonym Gene Names: Alpha-1B adrenoceptor
• UniProt Entry Name: ADA1B_HUMAN

NCBI Description

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

Uniprot Description

ADRA1B: a G protein-coupled catecholamine receptor that activates mitogenic responses and regulates growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Can induce neoplastic transformation when transfected into cell lines. Can regulate the phosphorylation status of the STAT3 pathway. Mediates blood pressure and aorta contractile responses induced by alpha-1 agonists. Activates a phosphatidylinositol second messenger system.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: integral to plasma membrane; nuclear membrane; nucleus; plasma membrane

Molecular Function: protein heterodimerization activity

Biological Process: cell proliferation; cell-cell signaling; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); glucose homeostasis; multicellular organismal development; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of MAPKKK cascade; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction