ACAP1 blocking peptide

ACAP1 Antibody (N-term) Blocking peptide

• Gene Names: ACAP1; CENTB1
• Synonyms: ACAP1; ACAP1 Antibody (N-term) Blocking peptide; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1; CENTB1; KIAA0050; ACAP1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 740

• Cellular Location: Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side
• Tissue Location: Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ACAP1 blocking peptide

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.

NCBI and Uniprot Product Information

• NCBI GI #: 3183210
• NCBI GeneID: 9744
• UniProt Accession #: Q15027; Q53XN9
• Molecular Weight: 81,536 Da
• NCBI Official Full Name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
• NCBI Official Synonym Full Names: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
• NCBI Official Symbol: ACAP1
• NCBI Official Synonym Symbols: CENTB1
• NCBI Protein Information: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
• UniProt Protein Name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
• Protein Family: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
• UniProt Gene Name: ACAP1
• UniProt Synonym Gene Names: CENTB1; KIAA0050; Cnt-b1
• UniProt Entry Name: ACAP1_HUMAN

Uniprot Description

CENTB1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol.

Protein type: GAPs, ARF; GAPs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane

Molecular Function: protein binding