Structure
YK-3-237 Biochemical
YK-3-237
Purity
>98% (HPLC)
Synonyms
YK-3-237; YK-3 237; YK-3-237 biochemical
Purity/Purification
>98% (HPLC)
Target
Sirtuin
Receptor
Sirtuin
Chemical Name
B-[2-methoxy-5-[(1E)-3-oxo-3-(3, 4, 5-trimethoxyphenyl)-1-propen-1-yl]phenyl]-boronic acid
SMILES
B(C1=C(C=CC(=C1)C=CC(=O)C2=CC(=C(C(=C2)OC)OC)OC)OC)(O)O
Molecular Formula
C19H21BO7
CAS Number
1215281-19-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for YK-3-237 biochemical
A novel small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53; demonstrates proliferation inhibition in breast cancer cell panel with EC50 of 0.1-5uM, also induces PARP-dependent apoptotic cell death and arrests the cell cycle at G2/M phase; enhances expression of alpha-SMA and fibronectin in cultured rat renal interstitial fibroblasts (NRK-49F).
Product Categories/Family for YK-3-237 biochemical
References
1. Yi YW, et al. Oncotarget. 2013 Jul; 4 (7):984-94.
2. Ponnusamy M, et al. J Pharmacol Exp Ther. 2015 Aug; 354 (2):142-51.
3. Kong Y, et al. Bioorg Med Chem. 2010 Jan 15; 18 (2):971-7.
2. Ponnusamy M, et al. J Pharmacol Exp Ther. 2015 Aug; 354 (2):142-51.
3. Kong Y, et al. Bioorg Med Chem. 2010 Jan 15; 18 (2):971-7.
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Product Notes
The YK-3-237 (Catalog #AAA3600805) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "YK-3-237, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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