Structure
Salermide, Inhibitor
Salermide
Purity
>98% (HPLC)
Synonyms
Salermide; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Sirtuin
Receptor
SIRT1; SIRT2
Chemical Name
Benzeneacetamide, N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-alpha-methyl
SMILES
O=C(NC1=CC=CC(/N=C/C2=C3C=CC=CC3=CC=C2O)=C1)C(C)C4=CC=CC=C4
Molecular Formula
C26H22N2O2
CAS Number
1105698-15-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Salermide, inhibitor
A potent Sirtuin inhibitor with IC50 of 76 and 45uM for SIRT1 and SIRT2, respectively; prompts tumour-specific cell death in a wide range of human cancer cell lines (MCF cells at 50uM), causes cell cycle arrest at G (1), results in the in vivo acetylation of the SIRT1/2 target p53, but not EX527.
Product Categories/Family for Salermide, inhibitor
References
1. Lara E, et al. Oncogene. 2009 Feb 12; 28 (6):781-91.
2. Peck B, et al. Mol Cancer Ther. 2010 Apr; 9 (4):844-55.
3. Rotili D, et al. J Med Chem. 2012 Dec 27; 55 (24):10937-47.
2. Peck B, et al. Mol Cancer Ther. 2010 Apr; 9 (4):844-55.
3. Rotili D, et al. J Med Chem. 2012 Dec 27; 55 (24):10937-47.
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Product Notes
The Salermide (Catalog #AAA3600403) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Salermide, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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