WIN 55, 212-2 mesylate Biochemical

WIN 55, 212-2 mesylate

Cat. Num. AAA3601277

• Purity: >98% (HPLC)
• Synonyms: WIN 55; 212-2 mesylate; R)-(+)-WIN 55212; WIN 55212-2; 212-2 mesylate biochemical

• Purity/Purification: >98% (HPLC)

• Suitability: DMSO: >=34mg/mL
• Target: Cannabinoid Receptor
• Receptor: CB1R; CB2R
• Chemical Name: Methanone, [(3R)-2, 3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1, 2, 3-de]-1, 4-benzoxazin-6-yl]-1-naphthalenyl-, methanesulfonate(1:1)
• SMILES: O=C(C1=C(C)N2[C@H](CN3CCOCC3)COC4=CC=CC1=C24)C5=C6C=CC=CC6=CC=C5.CS(=O)(O)=O
• Molecular Formula: C28H30N2O6S
• CAS Number: 131543-23-2
• Preparation and Storage: Store at -20 degree C; Stability: >=2 years; Shipping: Ice Pack

Structure

Related Product Information for WIN 55, 212-2 mesylate biochemical

WIN 55, 212-2 mesylate (WIN 55212-2) is a potent cannabinoid receptor agonist with Ki of 62.3 and 3.3nM for human recombinant CB1 and CB2 receptors, respectively; increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve at 0.01-100nM; increases dialysate glutamate levels the prefrontal cortex from of the awake rats, also demonstrates anticonvulsant effect in vivo pre-treated with 20mg/kg of pioglitazone.

Product Categories/Family for WIN 55, 212-2 mesylate biochemical

GPCR/G Protein; Neurological Disease

References

1. Felder CC, et al. Mol Pharmacol. 1995 Sep; 48 (3):443-50.
2. Griffin G, et al. J Pharmacol Exp Ther. 1998 May; 285 (2):553-60.
3. D'Ambra TE, et al. J Med Chem. 1992 Jan; 35 (1):124-35.
4. Martellotta MC, et al. Neuroscience. 1998 Jul; 85 (2):327-30.