Structure
T-3256336 Biochemical
T-3256336
Purity
>98% (HPLC)
Synonyms
T-3256336; T3256336; T 3256336; T-3256336 biochemical
Purity/Purification
>98% (HPLC)
Target
IAP
Receptor
IAP
Chemical Name
Pyrrolo[1, 2-a]pyrazine-3-carboxamide, 2-[(2S)-2-(4, 4-difluorocyclohexyl)-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-N-[(4R)-3, 4-dihydro-2H-1-benzopyran-4-yl]-7-ethoxyoctahydro-, (3S, 7R, 8aR)
SMILES
O=C([C@H]1N(C([C@H](C2CCC(F)(F)CC2)NC([C@H](C)NC)=O)=O)C[C@](C[C@@H](OCC)C3)([H])N3C1)N[C@@H]4CCOC5=C4C=CC=C5
Molecular Formula
C31H45F2N5O5
CAS Number
1266227-69-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for T-3256336 biochemical
A potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200nM for cIAP-1, cIAP-2 and XIAP, respectively; dose dependently antagonizes XIAP and promotes the activities of caspase-3 with EC50 of 1.3uM in cell-free assays, induces the rapid proteasomal degradation of cIAP-1 and activates TNF-alpha-dependent extrinsic apoptosis signaling in cultured cells; induces cIAP-1 degradation, TNF-alpha production and caspase activation in cancer xenograft models.
Product Categories/Family for T-3256336 biochemical
References
1. Sumi H, et al. Mol Cancer Ther. 2013 Feb; 12 (2):230-40.
2. Hashimoto K, et al. J Med Chem. 2013 Feb 14; 56 (3):1228-46.
3. Sumi H, et al. Biochem Biophys Res Commun. 2016 Oct 14; 479 (2):179-185.
2. Hashimoto K, et al. J Med Chem. 2013 Feb 14; 56 (3):1228-46.
3. Sumi H, et al. Biochem Biophys Res Commun. 2016 Oct 14; 479 (2):179-185.
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Product Notes
The T-3256336 (Catalog #AAA3601118) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "T-3256336, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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