Structure
AZD5582 Biochemical
AZD5582
Purity
>98% (HPLC)
Synonyms
AZD5582; AZD-5582; AZD5582 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=66.25mg/mL
Target
IAP
Receptor
IAP
Chemical Name
L-Prolinamide, 3, 3'-[2, 4-hexadiyne-1, 6-diylbis[oxy[(1S, 2R)-2, 3-dihydro-1H-indene-2, 1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl
SMILES
CN[C@@H](C)C(N[C@@H](C1CCCCC1)C(N2[C@H](C(N[C@H]3C(C=CC=C4)=C4C[C@H]3OCC#CC#CCO[C@@H]5CC6=C(C=CC=C6)[C@@H]5NC([C@H](CCC7)N7C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)=O)=O)CCC2)=O)=O.
Molecular Formula
C58H78N8O8
CAS Number
1258392-53-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZD5582 biochemical
AZD5582 is a dimeric Smac mimetic, potent IAP antagonist that binds potently to the BIR3 domains of cIAP1, cIAP2 and XIAP with IC50 of 15, 21and 15nM, respectively; causes cIAP1 degradation and induces apoptosis in the MDA-MB-231 breast cancer cell line at subnanomolar concentrations in vitro; induces cIAP1 degradation and caspase-3 cleavage within tumor cells and causes substantial tumor regressions in MDA-MB-231 xenograft-bearing mice.
References
1. Hennessy EJ, et al. J Med Chem. 2013 Dec 27; 56 (24):9897-919.
2. Moon JH, et al. Oncotarget. 2015 Sep 29; 6 (29):26895-908.
3. Zhuang J, et al. Pharmacol Res Perspect. 2014 Dec; 2 (6):e00081.
2. Moon JH, et al. Oncotarget. 2015 Sep 29; 6 (29):26895-908.
3. Zhuang J, et al. Pharmacol Res Perspect. 2014 Dec; 2 (6):e00081.
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Product Notes
The AZD5582 (Catalog #AAA3601064) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZD5582, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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