Structure
Prucalopride succinate Biochemical
Prucalopride succinate
Purity
>98% (HPLC)
Synonyms
Prucalopride succinate; R-108512; R108512; Prucalopride succinate biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=36mg/mL
Target
5-HT Receptor
Receptor
5-HT4A; 5-HT4B
Chemical Name
Butanedioic acid, compd. with 4-amino-5-chloro-2, 3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide(1:1)
SMILES
COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
Molecular Formula
C22H32ClN3O7
CAS Number
179474-85-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Prucalopride succinate biochemical
Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors; targets the impaired motility associated with chronic constipation, thus normalizing bowel movements; induces contractions (pEC50=7.48) in the guinea-pig colon, demonstrates anti-cholinergic, anticholinesterase or nonspecific inhibitory activity and does not antagonise 5-HT2A, 5-HT2B and 5-HT3 receptors or motilin, CCK1 receptors.
Product Categories/Family for Prucalopride succinate biochemical
References
1. Prins NH, et al. Br J Pharmacol. 1999 Jul; 127 (6):1431-7.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov; 13 (11):1493-7.
3. Bouras EP, et al. Gut. 1999 May; 44 (5):682-6.
4. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29; 423 (1):71-83.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov; 13 (11):1493-7.
3. Bouras EP, et al. Gut. 1999 May; 44 (5):682-6.
4. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29; 423 (1):71-83.
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Product Notes
The Prucalopride succinate (Catalog #AAA3602709) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Prucalopride succinate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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