Structure
RS 102221 Biochemical
RS 102221
Purity
>98% (HPLC)
Synonyms
RS 102221; RS102221; RS-102221; RS 102221 biochemical
Purity/Purification
>98% (HPLC)
Target
5-HT Receptor
Receptor
5-HT Receptor
Chemical Name
8-[5-(2, 4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1, 3, 8-triazaspiro[4.5]decane-2, 4-dione hydrochloride
SMILES
O=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O.[H]Cl
Molecular Formula
C27H31F3N4O7S.HCl
CAS Number
187397-18-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for RS 102221 biochemical
A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively; demonstrates 100-fold selectivity for the 5-HT2C versus 5-HT2A and 5-HT2B receptors; acts as an antagonist in a cell-based microphysiometry functional assay with pA2 of 8.1 and has no detectable intrinsic efficacy; increases food-intake and weight-gain in rats (2mg/kg, i. P.); reverses the inhibitory effects of MK-212 and DOI on 'monosynaptic and 'intermediate' neurones.
Product Categories/Family for RS 102221 biochemical
References
1. Bonhaus DW, et al. Neuropharmacology. 1997 Apr-May; 36 (4-5):621-9.
2. Bonhaus DW, et al. Ann N Y Acad Sci. 1998 Dec 15; 861:269.
3. Sievoz-Couche C, et al. Br J Pharmacol. 2000 Dec; 131 (7):1445-53.
4. McMahon LR, et al. J Neurosci. 2001 Oct 1; 21 (19):7781-7.
2. Bonhaus DW, et al. Ann N Y Acad Sci. 1998 Dec 15; 861:269.
3. Sievoz-Couche C, et al. Br J Pharmacol. 2000 Dec; 131 (7):1445-53.
4. McMahon LR, et al. J Neurosci. 2001 Oct 1; 21 (19):7781-7.
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Product Notes
The RS 102221 (Catalog #AAA3602904) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RS 102221, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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